Epidemiology and Ecology of Tularemia in Sweden, 1984–2012

نویسندگان

  • Amélie Desvars
  • Maria Furberg
  • Marika Hjertqvist
  • Linda Vidman
  • Anders Sjöstedt
  • Patrik Rydén
  • Anders Johansson
چکیده

The zoonotic disease tularemia is endemic in large areas of the Northern Hemisphere, but research is lacking on patterns of spatial distribution and connections with ecologic factors. To describe the spatial epidemiology of and identify ecologic risk factors for tularemia incidence in Sweden, we analyzed surveillance data collected over 29 years (1984-2012). A total of 4,830 cases were notified, of which 3,524 met all study inclusion criteria. From the first to the second half of the study period, mean incidence increased 10-fold, from 0.26/100,000 persons during 1984-1998 to 2.47/100,000 persons during 1999-2012 (p<0.001). The incidence of tularemia was higher than expected in the boreal and alpine ecologic regions (p<0.001), and incidence was positively correlated with the presence of lakes and rivers (p<0.001). These results provide a comprehensive epidemiologic description of tularemia in Sweden and illustrate that incidence is higher in locations near lakes and rivers.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Toward an Understanding of the Perpetuation of the Agent of Tularemia

The epidemiology of tularemia has influenced, perhaps incorrectly skewed, our views on the ecology of the agent of tularemia. In particular, the central role of lagomorphs needs to be reexamined. Diverse observations, some incidental, and some that are more generally reproducible, have not been synthesized so that the critical elements of the perpetuation of Francisella tularensis can be identi...

متن کامل

Clinical manifestations and the epidemiology of tularemia Klinička slika i epidemiologija tularemije

medicina fluminensis 2016, Vol. 52, No. 2, p. 211-216 211 Abstract. Francisella tularensis, the etiological agent of tularemia, was first recognized as a human pathogen more than 100 years ago. For several decades after its discovery, tularemia was a common disease in Soviet Union, the USA, and in certain parts of Eastern Europe but its importance in these countries has declined. In contrast, d...

متن کامل

Outbreaks of Tularemia in a Boreal Forest Region Depends on Mosquito Prevalence

BACKGROUND We aimed to evaluate the potential association of mosquito prevalence in a boreal forest area with transmission of the bacterial disease tularemia to humans, and model the annual variation of disease using local weather data. METHODS A prediction model for mosquito abundance was built using weather and mosquito catch data. Then a negative binomial regression model based on the pred...

متن کامل

Landscape Epidemiology of Tularemia Outbreaks in Sweden

Summer outbreaks of tularemia that occurred from 1995 through 2005 in 2 locations in Sweden affected 441 persons. We performed an epidemiologic investigation of these outbreaks using a novel strategy, involving high-resolution genotyping of Francisella tularensis isolates obtained from 136 patients (using 18 genetic markers developed from 6 F. tularensis genome sequences) and interviews with th...

متن کامل

Galantamine Effect on Tularemia Pathogenesis in a BALB/c Mouse Model

Background: Galantamine is a drug used for the treatment of Alzheimer’s disease and some other cognitive disorders. It is an inhibitor of acetylcholinesterase however, interaction with nicotinic acetylcholine receptors has also been reported. Owing to the significant role of cholinergic anti-inflammatory pathways in neuro-immunomodulation, we decided to examine the effect of galantamine on tula...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 21  شماره 

صفحات  -

تاریخ انتشار 2015